The proven absorption and bioavailability of TRIXSYN™ hyaluronan make TRIXSYN the safest, most convenient method of systemic and subtherapeutic supplementation.  When administered orally, the proprietary formulation of TRIXSYN ’s  hyaluronan is absorbed and distributed after a single oral administration.¹⁰

Oral hyaluronan appears as a burst in the serum within an hour and then decreases to background levels for several hours, followed by a steady serum hyaluronan increase for the next eighteen hours, in a time dependant manner. ⁹  A review of hyaluronan’s pharmacokinetics when labeled with ^99mtechnetium and orally administered to rats and canines was recently published.  Hyaluronan was seen as early as 30 minutes in the blood and found in the vertebrae and joints in 4 hours after a single administration.¹⁰   The scintigraphs below illustrate the conclusive evidence of absorption and distribution to organs, joints and vertebrae after a single oral administration.